TRISIALYLATED, GALACTOSYLATED, TRIANTENNARY
N-(2-Aminoethyl)-5-chloro-1-naphthalenesulfonamide, Hydrochloride
CAS: 78957-85-4
Molecular Formula: C12H14Cl2N2O2S
TRISIALYLATED, GALACTOSYLATED, TRIANTENNARY - Names and Identifiers
TRISIALYLATED, GALACTOSYLATED, TRIANTENNARY - Physico-chemical Properties
| Molecular Formula | C12H14Cl2N2O2S |
| Molar Mass | 321.22 |
| Melting Point | 173-176°C |
| Solubility | DMSO: 24mg/mL |
| Appearance | solid |
| Color | white |
| Storage Condition | -20°C |
| In vitro study | A-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the K i value is 7.4 μM. A-3 is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits K i values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively. |
TRISIALYLATED, GALACTOSYLATED, TRIANTENNARY - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
TRISIALYLATED, GALACTOSYLATED, TRIANTENNARY - Reference Information
| biological activity | A-3 hydrochloride are potent, cell-penetrating, reversible, and ATP-competitive non-selective antagonists targeting multiple kinases. A- 3 hydrochloride is an inhibitor of PKA (Ki = 4.3 µM), casein kinase II (Ki = 5.1 µM), and myosin light chain kinase (MLCK) (Ki = 7.4 µM). The A- 3 hydrochloride also inhibited the activity of PKC and casein kinase I with Ki of 47 µM and 80 µM, respectively. |
| target | CK1 80 μM (Ki) CK2 5.1 μM (Ki) PKC 47 μM (Ki) PKA 4.3 μM (Ki) |
| in vitro study | A- 3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that K I value is 7.4 μ m. a -3 is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits K I values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively. |
Last Update：2024-04-10 22:29:15
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